The risk of morbidity and mortality following recurrent malaria in Papua, Indonesia: A retrospective cohort study

S Dini; NM Douglas; JR Poespoprodjo; E Kenangalem; P Sugiarto; ID Plumb; RN Price; JA Simpson

Journal article

The risk of morbidity and mortality following recurrent malaria in Papua, Indonesia: A retrospective cohort study

S Dini, NM Douglas, JR Poespoprodjo, E Kenangalem, P Sugiarto, ID Plumb, RN Price, JA Simpson

BMC Medicine | BMC | Published : 2020

DOI: 10.1186/s12916-020-1497-0

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Abstract

Background: An acute episode of malaria can be followed by multiple recurrent episodes either due to re-infection, recrudescence of a partially treated parasite or, in the case of Plasmodium vivax or P. ovale, relapse from the dormant liver stage of the parasite. The aim of this study was to quantify the impact of recurrent malaria episodes on morbidity and mortality in Papua, Indonesia. Methods: We undertook a retrospective analysis of routinely collected data from malaria patients attending the primary referral hospital in Papua, Indonesia, between April 2004 and December 2013. Multi-state modelling was used to estimate the effect of recurring malaria episodes on re-presentation and admiss..

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University of Melbourne Researchers

Saber Dini Author

Julie Simpson Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

SD is funded by an NHMRC Project Grant (1100394) and an ARC Discovery Project (DP170103076). RNP is a Wellcome Trust Senior Fellow in Clinical Science (200909). JAS is funded by an Australian NHMRC Senior Research Fellowship 1104975. This work is supported in part by the Australian Centre for Research Excellence in Malaria Elimination, funded by the NHMRC (1134989).